Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens?

The occurrence and spreading of multidrug resistance in bacterial pathogens represent one the greatest challenges 21st century. With fewer new antibiotics development, novel unconventional concepts drug development formulation need to be explored overcome global crisis. Biomedical nanotechnology offers promising strategies for reformulation established such a way that they regain their activity against resistant pathogens. Herein, developments aimed at synthesis potent nanoparticle-based formulations glycopeptide are reviewed. While as vancomycin teicoplanin widely used drugs last resort Gram-positive methicillin-resistant Staphylococcus aureus (MRSA), these is spreading. However, inhibiting cell wall via binding precursor peptidoglycans, exhibit unique mode action renders them particularly candidates with ability antibiotic resistance. different based on multivalent presentation encapsulation introduced, conjugation discussed, an attempt made rationalize effects antibacterial resulting nanoparticle formulations.